YOON LAB
Department of Biological Sciences, KAIST
2022
1. Yoon, K.J.*, Kim, Y.K*. Resolving m6A epitranscriptome with stoichiometry. Trends in Genetics S0168-9525 (22) 00151-2 (Preview) (2022) (*co-corresponding authors) PDF
2. Koo, B., Lee, K.H., Ming, G.L., Yoon, K.J.*, Song, H*. Setting the clock of neural progenitor cells during mammalian corticogenesis. Seminars in Cell and Developmental Biology S1084-9521 (Review) (2022) (*co-corresponding authors) PDF
3. Jang, H., Kim, S.H., Koh, Y., Yoon, K.J. Engineering Brain Organoids: Toward Mature Neural Circuitry with an Intact Cytoarchitecture. International Journal of Stem Cells 15 (1), 41-59 (2022) PDF
4. Park, S., Ku, J., Lee, S.M., Hwang, H., Lee, N., Kim, H., Yoon, K.J., Kim, Y., Choi, S.Q. Potential toxicity of inorganic ions in particulate matter: Ion permeation in lung and disruption of cell metabolism. Science of the Total Environment 824:153818 (2022) PDF
5. Ringeling, F.R., Chakraborty, S., Vissers, C., Reiman, D., Patel, A.M., Lee, K.H., Hong, A., Park, C.W., Reska, T., Gagneur, J., Chang, H., Spletter, M.L., Yoon, K.J., Ming, G.L., Song, H., Canzar, S. Partitioning RNAs by length improves transcriptome reconstruction from short-read RNA-seq data. Nature Biotechnology (2022) PDF
2021
1. Kim, N.S., Ringeling, F.R., Zhou, Y., Nguyen, H.N., Temme, S.J., Lin, Y.T., Eacker, S., Dawson, V.L., Dawson, T.M., Xiao, B., Hsu, K.S., Canzar, S, Li, W, Worley, P, Christian, K. M., Yoon, K.J.*, Song, H., Ming, G.L*. CYFIP1 dosages exhibit divergent behavioral impact via diametric regulation of NMDAR complex translation in mouse models of psychiatric disorders. Biological Psychiatry (2021) (*co-corresponding authors) PDF
2. Kim, N.S., Wen, Z., Liu, J., Zhou, Y., Guo, Z., Xu, C., Lin, Y.T., Yoon, K.J., Park, J., Cho, M., Kim, M., Wang, X., Yu, H., Sakamuru, S., Christian, K.M., Hsu, K.S., Xia, M., Li, W., Ross, C.A., Margolis, R.L., Lu, X.Y., Song, H., Ming, G.L. Pharmacological rescue in patient iPSC and mouse models with a rare DISC1 mutation. Nature Communication 12 (1), 1398 (2021) PDF
3. Song, G, Lee, E.M., Pan, J., Xu, M., Rho, H.S., Cheng, Y., Whitt, N., Yang, S., Kouznetsova, J., Klumpp-Thomas, C., Michael, S.G., Moore, C., Yoon, K.J., Christian, K.M., Simeonov, A., Huang, W., Xia, M., Huang, R., Lal-Nag, M., Tang, H., Zheng, W., Qian, J., Song, H., Ming, G.L., Zhu, H. An Integrated Systems Biology Approach Identifies the Proteasome as A Critical Host Machinery for ZIKV and DENV Replication. Genomics Proteomics Bioinformatics (2021) PDF
2020
2019
1. Koo, B., Choi, B., Park, H., Yoon, K.J. Past, Present, and Future of Brain Organoid Technology. Molecules and Cells 42 (9), 617-627 (Review) (2019) PDF
2. Kim, J., Koo, B.K., Yoon, K.J. Modeling host-virus interactions in viral infectious diseases using stem-cell-derived systems and CRISPR/Cas9 technology. Viruses 11 (2), E124 (Review) (2019) PDF
2018
1. Zhou, Y, Bond, A.M., Shade, J.E., Zhu, Y., Davis, C.O., Wang, X., Su, Y., Yoon, K.J., Phan, A.T., Chen, W.J., Oh, J.H., Marsh-Armstrong, N., Atabai, K., Ming, G.L., Song, H. Autocrine Mfge8 signaling prevents developmental exhaustion of the adult neural stem cell pool. Cell Stem Cell 23 (3), 444-452 (2018) PDF
2. Yoon, K.J., Ming, G.L., Song, H. Epitranscriptomes in the adult mammalian brain: dynamic changes regulate behavior. Neuron 99 (2), 243-245 (Preview) (2018) PDF
3. Yoon, K.J., Vissers, C., Ming, G.L., Song, H. Epigenetics and epitranscriptomics in temporal patterning of cortical neural progenitor competence. Journal of Cell Biology 217 (6), 1901-1914 (Review) (2018) PDF
4. Yoon, K.J., Ming, G.L., Song, H. Coupling Neurogenesis to Circuit Formation. Cell 173 (Preview) (2018) PDF
1. Lee, J., Park, J., Kim, J.H., Lee, G., Park, T.E., Yoon, K.J., Kim, Y.K., Lim, C. LSM12-EPAC1 defines a neuroprotective pathway that sustains the nucleocytoplasmic RAN gradient. PLoS Biology 18 (12), eCollection (2020) PDF
2. Park, C.W., Lee, S.M., Yoon, K.J. Epitranscriptomic regulation of transcriptome plasticity in development and diseases of the brain. BMB Reports 53 (11), 551-564 (Review) (2020) PDF
3. Lee, J., Yoon, K.J., Park, P., Lee, C., Kim, M.J., Han, D.H., Kim, J.I., Kim, S., Lee, H.R., Lee, Y., Jang, E.H., Ko, H.G., Kong, Y.Y., Kaang, B.K. Neur1 and Neur2 are required for hippocampus-dependent spatial memory and synaptic plasticity. Hippocampus 30 (11), 1158-1166 (2020) PDF
4. Habela, C., Yoon, K.J., Kim, N.S., Taga, A., Bell, K., Bergles, D., Maragakis, N., Ming, G.L., Song, H. Persistent Cyfip1 expression is required to maintain the adult subventricular zone neurogenic niche. Journal of Neuroscience 40 (10), 2015-2024 (2020) PDF
2017
1. Song, G., Rho, H.S., Pan, J., Ramos, P., Yoon, K.J., Medina, F.A., Lee, E.M., Eichnger, D.J., Ming, G.L., Munoz-Jordan, J.L., Tang, H., Pino, I., Song., H., Qian, J., Zhu, H. Multiplexed biomarker panels discriminate Zika and Dengue virus infection in humans. Molecular and Cellular Proteomics mcp. RA117 PDF
2. Yoon, K.J.*, Ringeling, F.R.*, Vissers, C.*, Jacob, F., Pokrass, M., Jimenez-Cyrus, D., Su, Y., Kim, N.S., Zhu, Y., Zheng, L., Kim, S., Wang, X., Hyde, T.M., Weinberger, D.R., Jin, P., Zhuang, X., Regot, S., Regot, S., Canzar, S., He, C., Ming, G.L., Song, H. Temporal Control of Mammalian Cortical Neurogenesis by m6A mRNA Methylation. Cell 171, 1–13 (2017) (*equal contribution) PDF
Highlighted with a “News and views” article in Nature 551(7681), 448-449 PDF
Previewed in Neuron 96(4), 718-720 PDF
3. Yoon, K.J., Song, G., Qian, X., Pan, J., Rho, H.S., Kim, N.S., Habela, C., Zheng, L., Jacob, F., Zhang, F., Lee, E.M., Huang, W.K., Ringeling, F.R., Vissers, C., Li, C., Yuan, L., Kang, K., Kim, S., Yeo, J., Cheng, Y., Liu, S., Wen, Z., Qin, C.F., Wu, Q., Christian, K.M., Tang, H., Jin, P., Xu, Z., Qian, J., Zhu, H., Song, H., Ming, G.L. Zika-virus-encoded NS2A disrupts mammalian cortical neurogenesisby degrading adherens junction proteins. Cell Stem Cell 21(3), 349-358 PDF
2016
1. Zhang, F., Hammack, C., Ogden S.C., Cheng, Y, Lee, E.M., Wen, Z., Qian, X., Nguyen, H.N., Li, Y., Yao, B., Xu, M., Xu, T., Chen, L., Wang, Z., Feng, H., Huang, W.K., Yoon, K.J., Shan, C., Huang, L., Qin, Z., Christian, K.M., Shi, P.Y., Xu, M., Xia, M., Zheng, W., Wu, H., Song, H., Tang, H., Ming, G.L., Jin, P. Molecular signatures associated with ZIKV exposure in human cortical neural progenitors. Nuclear Acid Research 44(18), 8610-8620 PDF
2. Qian, X, Nguyen, H.N., Song, M.M., Hadiono, C., Ogden, S.C., Hammack, C, Yao, B, Hamersky, G.R., Jacob, F., Zhong, C., Yoon, K.J., Jeang, W.,Lin, L., Li, Y., Thakor, J., Berg, D.A., Zhang, C., Kang, E.C., Chickering, M., Nauen, D., Ho, C.Y.,Wen, Z., Christian, K.M., Shi, P.Y., Maher, B.J.,Wu, H., Jin, P., Tang, H.,Song, H. and Ming, G.L. Brain-region-specific organoids using mini-bioreactors for modeling ZIKV exposure. Cell 165(5), 1238-1254 PDF
2014 - 2015
1. Berg, D.A.*, Yoon, K.J.*, Will B., Xiao, A.Y, Kim, N.S., Christian, K.M., Song, H., Ming, G.L. Tbr2-expressing intermediate progenitor cells in the adult mouse hippocampus are unipotent neuronal precursors with limited amplification capacity under homeostasis. Frontiers in Biology 10(3), 262-271 (2015) (*equal contribution) PDF
2. Wen, Z., Nguyen, H.N., Guo, Z., Lalli, M.A., Wang, X., Su, Y., Kim, N.S., Yoon, K.J., Shin, J., Zhang, C., Makri, G., Nauen, D., Yu, H., Guzman, E., Chiang, C.H., Yoritomo, N., Kaibuchi, K., Zou, J., Christian, K.M., Cheng, L., Ross, C.A., Margolis, R.L., Chen, G., Kosik, K.S., Song, H., Ming, G.L. Synaptic dysregulation in a human iPS cell model of mental disorders. Nature 515, 414–418 (2014) PDF
3. Yoon, K.J., Nguyen, H.N., Ursini, G, Zhang, F, Kim, N.S., Wen, Z., Makri, G., Nauen, D., Shin, J.H., Park, Y., Chung, R., Pekle, E., Zhang, C., Towe, M., Lee, Y., Rujescu, D., St. Clair, D., Kleinman, J.E., Hyde, T.M., Christian, K.M., Rapoport, J.L., Weinberger, D.R., Song, H., Ming, G.L. Modeling a genetic risk for schizophrenia in iPSCs and mice reveals neural stem cell deficits associated with adherens junctions and polarity. Cell Stem Cell 15(1), 79-91 (2014) Cover and Featured Article PDF
Previewed in Cell Stem Cell 15(1), 4-5 (2014) PDF
Highlighted in Nature Medicine 20(8), 813 (2014) PDF
2005 - 2013
1. Yoon, K.J. *, Lee, H.R.*, Jo, Y.S., An, K., Jung, S.Y., Jeong, M.W., Kwon, S.K., Kim, N.S., Jeong, H.W., An, H.S., Kim, K.T., Lee, K., Kim, E., Kim, J.H., Choi, J.S., Kaang, B.K., Kong, Y.Y. Mind bomb-1 is an essential modulator of long-term memory and synaptic plasticity via the Notch signaling pathway. Mol Brain 5(1), 40 (2012) (*equal contribution) PDF
2. Kim, N.S., Kim, H.T., Choi, S.W., Kim, Y.Y., Yoon, K.J., Koo, B.K., Kong, M.P., Shin, J., Cho, Y., Kong, Y.Y. Survival and differentiation of mammary epithelial cells in mammary gland development require nuclear retention of Id2 due to RANK signaling. Molecular and Cellular Biology (2011) PDF
3. Jung, Y.J., Park, Y.S., Yoon, K.J., Kong, Y.Y., Park, J.W., Nam, H.G. Molecule-level imaging of Pax6 mRNA distribution in mouse embryonic neocortex by molecular interaction force microscopy. Nucleic Acids Research 37(2), e10 (2009) PDF
4. Song, R., Kim, Y.W., Koo, B.K., Jeong, H.W., Yoon, M.J., Yoon, K.J., Jun, D.J., Im, S.K., Shin, J., Kong, M.P, Kim, K.T, Yoon, K., Kong, Y.Y. Mind bomb 1 in the lymphopoietic niches is essential for T and marginal zone B cell development. Journal of Experimental Medicine 205, 2525-2536 (2008) PDF
5. Yoon, K.J., Koo, B.K., Im, S.K., Jeong, H.W., Ghim, J., Kwon, M.C., Moon, J.S., Miyata, T., and Kong, Y.Y. Mind bomb 1-expressing intermediate progenitors generate notch signaling to maintain radial glial cells. Neuron 58, 519-531 (2008) PDF
6. Kwon, M.C., Koo, B.K., Moon, J.S., Kim, Y.Y., Park, K.C., Kim, N.S., Kwon, M.Y., Kong, M.P., Yoon, K.J., Im, S.K., Ghim, J., Han, Y.M., Jang, S., Shong, M., and Kong, Y.Y. Crif1 is a novel transcriptional coactivator of STAT3. EMBO Journal (27), 642-653 (2008) PDF
7. Koo, B.K.*, Yoon, M.J.*, Yoon, K.J.*, Im, S.K., Kim, Y.Y., Kim, C.H., Suh, P.G., Jan, Y.N., and Kong, Y.Y. An obligatory role of mind bomb-1 in notch signaling of mammalian development. PLoS ONE 2, e1221 (*equal contribution) (2007) PDF
8. Song, R., Koo, B.K., Yoon, K.J., Yoon, M.J., Yoo, K.W., Kim, H.T., Oh, H.J., Kim, Y.Y., Han, J.K., Kim, C.H., and Kong, Y.Y. Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1. Journal of Biological Chemistry 281, 36391-36400 (2006) PDF
9. Yoo, K.W., Kim, E.H., Jung, S.H., Rhee, M., Koo, B.K., Yoon, K.J., Kong, Y.Y., and Kim, C.H. Snx5, as a Mind bomb-binding protein, is expressed in hematopoietic and endothelial precursor cells in zebrafish. FEBS Letters 580, 4409-4416 (2006) PDF
10. Koo, B.K., Lim, H.S., Song, R., Yoon, M.J., Yoon, K.J., Moon, J.S., Kim, Y.W., Kwon, M.C., Yoo, K.W., Kong, M.P., Lee J, Chitnis A.B., Kim C.H. and Kong Y.Y. Mind bomb 1 is essential for generating functional Notch ligands to activate Notch. Development 132, 3459-3470 (2005) PDF
11. Koo, B.K., Yoon, K.J., Yoo, K.W., Lim, H.S., Song, R., So, J.H., Kim, C.H., and Kong, Y.Y. Mind bomb-2 is an E3 ligase for Notch ligand. Journal of Biological Chemistry 280, 22335-22342 (2005) PDF